abstract：:Eradication of Helicobacter pylori infection is known to reduce the incidence of duodenal ulcer recurrence. The most commonly used regimen for H. pylori infection is triple antimicrobial therapy for 1-2 weeks. This treatment is associated with frequent side effects and hence unsatisfactory compliance. As in vitro data...

journal_title：Journal of gastroenterology and hepatology

authors： Sung JJ,Chung SC,Hosking SW,Chan RC,Ling TK,Yung MY,Cheng AF,Li AK

更新日期：1995-01-01 00:00:00

abstract：:The expression of thrombomodulin on sinusoidal endothelial cells was studied using the immuno-peroxidase method and both light and electron microscopy in patients with chronic viral hepatitis (type B: four cases; type C: 28 cases). Thrombomodulin was found on sinusoidal endothelial cells, especially on the surface in ...

journal_title：Journal of gastroenterology and hepatology

authors： Zeniya M,Fukata H,Toda G

更新日期：1995-01-01 00:00:00

abstract：:Sinusoidal endothelial cell damage is produced by activation of hepatic macrophages after endotoxin administration in rats pretreated with Cornyebacterium parvum or undergoing 70% hepatectomy. Such damage causes fibrin deposition in the hepatic sinusoids leading to massive hepatic necrosis. In the C. parvum model, cyt...

journal_title：Journal of gastroenterology and hepatology

authors： Mochida S,Ohno A,Arai M,Fujiwara K

更新日期：1995-01-01 00:00:00

abstract：:The subjects of this study were 151 patients (69 males and 82 females) who underwent examination and liver biopsy owing to liver dysfunction in an epidemic area with hepatitis C. Second generation hepatitis C virus antibody (HCV Ab) was positive in 116 (76.8%) of 151 cases. HCV-RNA was detected in 120 (79.5%) by polym...

journal_title：Journal of gastroenterology and hepatology

authors： Yamada M,Fukuda Y,Imoto M,Koyama Y,Hayakawa T,Takayama T,Nagura H

更新日期：1994-11-01 00:00:00

abstract：:Endoscopic variceal ligation (EVL) related complication is rarely reported. A case is presented of a 74 year old man with oesophageal variceal bleeding who developed oesophageal perforation following EVL and balloon tamponade. An oesophageal wall defect was induced by EVL and tissue repair was hindered by decompensate...

journal_title：Journal of gastroenterology and hepatology

authors： Hou MC,Lin HC,Chang FY,Lee FY,Chen TS,Lee SD

更新日期：1994-11-01 00:00:00

abstract：:In order to study the process of hepatocellular carcinoma (HCC) development, and to search for a clue to histologic diagnosis of well-differentiated HCC (wd-HCC), interstitial invasion in small HCC was evaluated. The study material consisted of 35 cases of HCC that were smaller than 3 cm that comprised 17 cases of wd-...

journal_title：Journal of gastroenterology and hepatology

authors： Kondo F,Kondo Y,Nagato Y,Tomizawa M,Wada K

更新日期：1994-11-01 00:00:00

abstract：:Patients with Crohn's disease of the distal ileum show increased permeability to hyaluronan and increased release of histamine and complement components in uninvolved parts of the proximal jejunum. These abnormalities are related to disease activity, and are not found in first-degree relatives. Increased synthesis of ...

journal_title：Journal of gastroenterology and hepatology

authors： Ahrenstedt O,Hällgren R,Knutson L

更新日期：1994-11-01 00:00:00

abstract：:Bleeding from hepatocellular carcinoma (HCC) invading the gastrointestinal tract is very uncommon. We report the case of a 61 year old man who had a large bleed from HCC invading the fundus of the stomach. Diagnosis was eventually made at laparotomy and he is still alive 7 months after local resection. ...

journal_title：Journal of gastroenterology and hepatology

authors： Nicoll AJ,Ireton HJ,Crotty B

更新日期：1994-09-01 00:00:00

abstract：:In order to detect both pancreatic excretion of dimethadione (DMO), a weak organic acid, and the effect of pancreatic DMO on secretin-stimulated pancreatic secretion, DMO was given intravenously to dogs with pancreatic fistulae at a dose of 50, 100 and 200 mg/kg. DMO was promptly excreted into pancreatic juice; the co...

journal_title：Journal of gastroenterology and hepatology

authors： Noda A,Takeuchi K,Murayama H,Ibuki E,Okumura I,Okuyama M,Okayama T,Kobayashi T

更新日期：1994-09-01 00:00:00

abstract：:Proliferating tumour cells in 92 patients with hepatocellular carcinoma (HCC) were identified by an immunohistochemical method using a monoclonal antibody against proliferating cell nuclear antigen (PCNA). The rate of PCNA-positive cells in HCC tissues was positively correlated with histological grade and the tumour s...

journal_title：Journal of gastroenterology and hepatology

authors： Nishimori H,Tsukishiro T,Nambu S,Okada K,Shimizu Y,Miyabayashi C,Higuchi K,Watanabe A

更新日期：1994-09-01 00:00:00

abstract：:The polymerase chain reaction (PCR) was used to examine expression of interferon-alpha (IFN A) genes in general and the expression of messenger RNA (mRNA) encoding the subtypes IFN-alpha-2 and IFN-alpha-4 in blood and liver biopsy samples from patients with chronic hepatitis C or hepatitis non-A, non-B (HC/HNANB) infe...

journal_title：Journal of gastroenterology and hepatology

authors： Brandt ER,Devenish RJ,Hertzog PJ,Dudley FJ,Linnane AW

更新日期：1994-07-01 00:00:00

abstract：:The main purpose of the present study was to demonstrate the incidence of Paneth cells in colorectal tubular adenomas of Japanese descendants in Hawaii. Paneth cells were found in 73 of 322 adenomas (22.7%) of Japanese descendants in Hawaii. The incidence of Paneth cells in adenomas located from the caecum to the tran...

journal_title：Journal of gastroenterology and hepatology

authors： Wada R,Kuwabara N,Suda K

更新日期：1994-05-01 00:00:00

abstract：:This study evaluates the immune response of 20 haemodialysis (HD) patients vaccinated with hepatitis A (HA) vaccine and eight patients vaccinated with hepatitis B (HB) vaccine. Twenty patients and 22 healthy adults were immunized three times (months 0, 1 and 6) intramuscularly with a 0.5 microgram dose. All members of...

journal_title：Journal of gastroenterology and hepatology

authors： Kuramoto I,Fujiyama S,Matsushita K,Sato T

更新日期：1994-05-01 00:00:00

abstract：:Forty-six patients with primary biliary cirrhosis from a single centre were studied in a randomized placebo-controlled trial to determine the effectiveness of ursodeoxycholic acid (UDCA) over a 2 year period. The two groups were well-matched at baseline. For each parameter, by calculating the difference between the me...

journal_title：Journal of gastroenterology and hepatology

authors： Turner IB,Myszor M,Mitchison HC,Bennett MK,Burt AD,James OF

更新日期：1994-03-01 00:00:00

abstract：:Mucus and bicarbonate secretions have been widely implicated as an important pre-epithelial protective barrier against autodigestion of the gastric mucosa by acid and pepsin. Evidence from several independent studies shows there is a continuous layer of resilient viscoelastic mucus gel adherent to the surface of the g...

journal_title：Journal of gastroenterology and hepatology

authors： Copeman M,Matuz J,Leonard AJ,Pearson JP,Dettmar PW,Allen A

更新日期：1994-01-01 00:00:00

abstract：:At Royal Perth Hospital, Western Australia in April 1982, spiral bacteria were first cultured from a gastric biopsy specimen. Several important taxonomic features were identified which indicated that these bacteria represented a new genus. In October 1989 the new genus name Helicobacter was published. Helicobacter pyl...

journal_title：Journal of gastroenterology and hepatology

authors： Goodwin CS

更新日期：1994-01-01 00:00:00

abstract：:Lymphocytic (microscopic) colitis is a disease of unknown aetiology which manifests as long-standing intermittent diarrhoea. Diagnosis is confirmed on histological examination of the colon. An association of this uncommon disease with tropical sprue is described. Tetracycline therapy resulted in a favourable clinical ...

journal_title：Journal of gastroenterology and hepatology

authors： Puri AS,Khan EM,Kumar M,Pandey R,Choudhuri G

更新日期：1994-01-01 00:00:00

abstract：:To identify the preneoplastic lesions of hepatocellular carcinoma and the fine structure of preneoplastic hepatocytes, we studied proliferative conditions in cirrhosis of the liver. In all, 46 foci of cellular alteration (FCA), three regions of adenomatous hyperplasia (ADH), and 21 small hepatocellular carcinomas (sHC...

journal_title：Journal of gastroenterology and hepatology

authors： Seki S,Sakaguchi H,Kawakita N,Yanai A,Tamori A,Yabusako T,Nishiguchi S,Kuroki T,Kobayashi K,Monna T

更新日期：1993-11-01 00:00:00

abstract：:A 67 year old male with non-resectable hepatocellular carcinoma (HCC) in both lobes and liver cirrhosis was treated with transcatheter arterial embolization and regional chemotherapy. He was doing well for 18 months. He was readmitted for fever, chest pain and multiple pulmonary metastases. During interleukin-2 therap...

journal_title：Journal of gastroenterology and hepatology

authors： Akimaru K,Miyairi K,Tanaka H,Imai S,Iwase I,Uchiyama K,Shibuya T,Shoji T

更新日期：1993-11-01 00:00:00

abstract：:The exact pathogenesis of centrilobular necrosis following congestion of the liver is still unknown. We reviewed the clinical data related to systemic circulatory disturbance and histopathology of the liver and the gut in 320 autopsy subjects. Congestion of the liver alone was associated only with atrophy and loss of ...

journal_title：Journal of gastroenterology and hepatology

authors： Shibayama Y,Urano T,Asaka S,Hashimoto K,Nakata K

更新日期：1993-11-01 00:00:00

abstract：:A hepatitis B virus (HBV) carrier with marked retention of indocyanine green (ICG) and sulfobromophthalein (BSP) was admitted to our hospital for assessment of liver function. On admission, he was asymptomatic and blood chemistry tests showed normal values for transaminases and bilirubin. Serum hepatitis B surface ant...

journal_title：Journal of gastroenterology and hepatology

authors： Ikejima K,Ichikawa S,Kitamura T,Watanabe S,Hirose M,Yokoi Y,Uchida S,Oide H,Suzuki H,Kitami N

更新日期：1993-09-01 00:00:00

abstract：:To investigate the effect of hepatitis delta virus (HDV) superinfection on the long-term outcome of Japanese subjects with chronic hepatitis B virus (HBV) infection, we examined the presence of antibodies to hepatitis delta antigen (anti-HD) in serial serum samples collected from 1127 subjects with chronic HBV infecti...

journal_title：Journal of gastroenterology and hepatology

authors： Tamura I,Kurimura O,Koda T,Ichimura H,Katayama S,Kurimura T,Inaba Y

更新日期：1993-09-01 00:00:00

abstract：:The mechanism of phagocytosis by Kupffer cells has been shown to be related to the Ca(2+)-calmodulin and the actomyosin systems. However the role of the transmembrane signal transmitter, G-protein, is still unknown. In this study, a quantitative evaluation of phagocytosis by Kupffer cells of rats in culture and the ef...

journal_title：Journal of gastroenterology and hepatology

authors： Hirose M,Watanabe S,Ueno T,Kitami N,Sato N

更新日期：1993-07-01 00:00:00

abstract：:The immunogenicity and adverse reaction of an inactivated hepatitis A (HA) vaccine were investigated. Sixty healthy adult volunteers who lacked antibody to HA virus (anti-HAV) received three doses of vaccine containing 720 enzyme-linked immunosorbent assay (ELISA) units (EL.U) according to a 0, 1 and 6 month schedule....

journal_title：Journal of gastroenterology and hepatology

authors： Horng YC,Chang MH,Lee CY,Safary A,Andre FE,Chen DS

更新日期：1993-07-01 00:00:00

abstract：:Patients with end-stage liver disease have significant mortality often associated with intercurrent episodes of bleeding or sepsis. Intact adrenal function is essential in such situations. In order to test the hypothesis that adrenal insufficiency might be present in severe liver disease, hypothalamic-pituitary adrena...

journal_title：Journal of gastroenterology and hepatology

authors： McDonald JA,Handelsman DJ,Dilworth P,Conway AJ,McCaughan GW

更新日期：1993-05-01 00:00:00

abstract：:Differentiation between gastric adenomas and type IIa early gastric cancer by macroscopic and histologic examinations is often difficult. This study has shown that there are differences in the distribution of S-phase cells in these two types of tumour, and these differences can be exploited to differentiate between th...

journal_title：Journal of gastroenterology and hepatology

authors： Miwa H,Wada R,Abe H,Ohkura R,Yang SW,Watanabe H,Ogihara T,Hamada T,Sato N

更新日期：1993-03-01 00:00:00

abstract：:Acute suppurative cholangitis is one of the common causes of acute abdomen in Taiwan. Emergency decompression is a life-saving procedure if patients fail to respond to antibiotic treatment. From July 1988 to June 1991, 224 patients were encountered with concomitant bile duct stones and cholangitis; 40 were brought to ...

journal_title：Journal of gastroenterology and hepatology

authors： Lin XZ,Chang KK,Shin JS,Lin CY,Lin PW,Yu CY,Chou TC

更新日期：1993-01-01 00:00:00

abstract：:Ceftriaxone-associated sludge has been a fascinating story. The occurrence is novel and unique. It has produced a model of gall-bladder sludge in humans. This phenomenon has taught us a great deal about biliary lipid and organic anion excretion by the liver, and the physical chemistry of calcium and calcium sensitive ...

journal_title：Journal of gastroenterology and hepatology

authors： Kim YS,Kestell MF,Lee SP

更新日期：1992-11-01 00:00:00

abstract：:The three-dimensional ultrastructure of nuclei and cell organelles including rough-surfaced endoplasmic reticulum (RER), mitochondria, and cytoskeleton were studied in normal rat hepatocytes by the quick-freezing and deep-etching method. Peroxisomes and mitochondria were observed as spherical structures with granular ...

journal_title：Journal of gastroenterology and hepatology

authors： Furuta K,Ohno S,Gibo Y,Kiyosawa K,Furuta S

更新日期：1992-09-01 00:00:00

abstract：:The author visited China in 1981 and 1984 and obtained data comparing the incidence of duodenal ulcer in the rice eating districts of the south with the incidence in the wheat, maize and millet eating areas of the north. The evidence suggested a higher prevalence of duodenal ulcer in the rice eating areas than in the ...

journal_title：Journal of gastroenterology and hepatology

authors： Tovey FI

更新日期：1992-07-01 00:00:00

abstract：:A case of persistent ileitis following the refashioning of a Kock ileal pouch into a Brooke ileostomy for severe pouchitis is reported. Preserving the terminal ileum by a salvage procedure may not be a safe alternative to pouch excision with the formation of a new end ileostomy in the surgical management of pouchitis ...

journal_title：Journal of gastroenterology and hepatology

authors： de Silva HJ,Mortensen NJ

更新日期：1992-07-01 00:00:00

abstract：:The aetiology of idiopathic portal hypertension or hepatoportal sclerosis is unknown. In view of the indirect evidence for underlying immunologic abnormalities 14 patients (all middle-aged females) were studied. Various auto-antibodies were demonstrated in seven patients and high levels of serum immunoglobulins, eithe...

journal_title：Journal of gastroenterology and hepatology

authors： Tokushige K,Komatsu T,Ohzu K,Yamauchi K,Obata H

更新日期：1992-05-01 00:00:00

abstract：:There is some evidence of an antagonism between peptic ulcer and diabetes mellitus. This antagonism is possibly related to anomalous insulin metabolism in duodenal ulcer patients. To evaluate this issue, 471 Rochester, Minnesota residents who had surgery for peptic ulcer were examined and then followed for up to 34 ye...

journal_title：Journal of gastroenterology and hepatology

authors： Duggan JM,O'Keefe EA,Weaver AL,Zinsmeister AR,Melton LJ 3rd

更新日期：1992-05-01 00:00:00

abstract：:A prospective double blind and randomized study was conducted to compare 4-aminosalicylic acid (4-ASA) and prednisolone-21-phosphate enemas in inducing remission in patients with acute distal ulcerative colitis. Patients with ulcerative colitis distal to the splenic flexure as assessed by flexible colonoscopy, barium ...

journal_title：Journal of gastroenterology and hepatology

authors： Sharma MP,Duphare HV,Dasarathy S

更新日期：1992-03-01 00:00:00

abstract：:This study examined Na+/H+ ion exchange of caecal and colonic mucus. Two distinct Na+/H+ ion exchange populations of caecal mucus were identified, one group being a cation exchanger and the other an anion exchanger, suggesting that caecal mucus has ampholyte properties responsive to changing physical and chemical prop...

journal_title：Journal of gastroenterology and hepatology

authors： Duncan CE,Tasman-Jones C

更新日期：1992-01-01 00:00:00

abstract：:We evaluated the clinical usefulness of a protein induced by vitamin K absence, antagonist-prothrombin (PIVKA-II), in detecting hepatocellular carcinoma (HCC) specifically in patients with liver cirrhosis, and the possible correlation between levels of PIVKA-II and pathological features of HCC. Plasma levels of PIVKA-...

journal_title：Journal of gastroenterology and hepatology

authors： Takikawa Y,Suzuki K,Yamazaki K,Goto T,Madarame T,Miura Y,Yoshida T,Kashiwabara T,Sato S

更新日期：1992-01-01 00:00:00

abstract：:Epidemiological evidence consistently indicates that aspirin or non-aspirin non-steroidal anti-inflammatory drug use is associated with the occurrence of gastric ulceration, gastric and ulcer bleeding, and ulcer death. Evidence on duodenal ulcer occurrence conflicts, possibly because of differences in study population...

journal_title：Journal of gastroenterology and hepatology

authors： Langman MJ,Brooks P,Hawkey CJ,Silverstein F,Yeomans N

更新日期：1991-09-01 00:00:00

abstract：:A randomized controlled trial was designed to investigate whether a high dose of terlipressin could control acute variceal haemorrhage more effectively than a low dose of terlipressin. Forty cirrhotic patients with bleeding oesophageal varices were included, with low-dose terlipressin in 21 patients and high-dose terl...

journal_title：Journal of gastroenterology and hepatology

authors： Chang TT,Lee FY,Tsai YT,Lai KH,Chao Y,Hsia HC,Lin HC,Wang SS,Lee SD,Lo KJ

更新日期：1991-09-01 00:00:00

abstract：:A 57 year old Japanese male was incidentally found to have a 7.5 cm diameter hepatic haemangioma. Eleven years later he was operated on because the haemangioma had grown into a 17 cm mass causing upper abdominal fullness. Volumetry on computerized tomograms disclosed that the haemangioma had grown from 123 cm3 to 1343...

journal_title：Journal of gastroenterology and hepatology

authors： Yoshida J,Yamasaki S,Yamamoto J,Kosuge T,Takayama T,Hasegawa H,Takayasu K,Muramatsu Y,Moriyama N,Hirohashi S

更新日期：1991-07-01 00:00:00

abstract：:The purpose of tumour staging for colorectal cancer (CRC) is to help define clinical management, facilitate communication between physicians, provide a basis for stratification and analysis of treatment results in prospective studies, and provide some prognostic information for patients and their families. The World C...

journal_title：Journal of gastroenterology and hepatology

authors： Fielding LP,Arsenault PA,Chapuis PH,Dent O,Gathright B,Hardcastle JD,Hermanek P,Jass JR,Newland RC

更新日期：1991-07-01 00:00:00